The AO Research Institute Davos is seeking a postdoc with a strong background in biopolymer chemistry and biomaterials!
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First and Last Name: Ksenia Menshikh Student/PhD/Postdoc: PhD Candidate Institute: Università del Piemonte Orientale Department: Department of Health Sciences Group leader: Prof. Lia Rimondini (INNOVATION Lab) Matrix Marvel: Stem Cells Thriving on Bone-Mimicking Scaffolds Short description of image: In our studies, I am searching for a synthetic scaffold suitable for the use as a bone-like environment in 3D models of skeletal diseases in vitro. This scanning electron microscopy image shows extracellular matrix (pink) produced by primary mesenchymal stem cells seeded on the 3D-printed tricalcium phosphate scaffold (its granules are in blue). * The fact that the cells produced abundant amounts of matrix and integrated in the scaffold’s microstructure indicates that the tricalcium phosphate scaffold is cytocompatible and can potentially play role of a bone-like environment - at least, from the point of observations in vitro. Instrument used to produce the image: Scanning Electron Microscope JSM-IT500 by Leica.
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Anna RUBINA
MS.
LATVIA Riga Technical University Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre
Biography
I am a research assistant at the Institute of Biomaterials and Bioengineering at Riga Technical University. With 3 years of experience in biomaterials science, I specialize in the development of injectable composite materials for drug/ion delivery for bone tissue regeneration. I hold a Bachelor’s degree in Chemical Technology from Riga Technical University and am expected to obtain my Master’s degree in June 2024.
I have published in reputable journals such as ACS Applied Bio Materials and presented at national and international conferences, including the 32nd and 33rd Annual Conference of the European Society for Biomaterials (ESB). I am part of the Baltic Biomaterials Centre of Excellence (BBCE) project, which collaborates with AO Research Institute Davos, Switzerland (ARI) and the Friedrich-Alexander University of Erlangen-Nuremberg, Germany (FAU), and aims to develop patient-specific solutions for tissue regeneration from material design to clinical trials.
I am particularly interested in developing injectable composite hydrogels based on calcium phosphates and natural polymers for filling bone defects caused by osteoporosis or osteomyelitis. I am committed to advancing bone-targeted biomaterials science and actively collaborate with other researchers in this field.
Expertise
I have worked extensively with calcium phosphate and hydrogel synthesis, as well as composite hydrogel development. In the last three years i have gained experience in such analytical techniques as XRD, FTIR, SEM, UV-vis, ICP-MS, Micro-CT etc.
Publications
• L. Stipniece, A. Ramata-Stunda, J. Vecstaudza, I. Kreicberga, D. Livkisa, A. Rubina, A. Sceglovs, K. Salma-Ancane. “A comparative study on physicochemical properties and in vitro biocompatibility of Sr-substituted and Sr ranelate-loaded hydroxyapatite nanoparticles,” ACS Appl. Bio Mater. 6 (2023) 5264–5281. https://doi.org/10.1021/acsabm.3c00539. (published December 1st 2023)
• “Injectable mineralized Sr-hydroxyapatite nanoparticles-loaded ɛ- polylysine-hyaluronic acid composite hydrogels for bone regeneration” (submitted in International Journal of Biological Macromolecules (IF 8.2) in 9th April 2024).
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