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Welcome to the European Society for Biomaterials

A year-long 'virtual environment' where scientists, clinicians, industrials and regulatory affairs experts can network.

Picture contest

Application Scientific Image Competition

First and Last Name: Viswanath Vittaladevaram
Student/PhD/Postdoc: PhD Researcher
Institute: University of Galway
Department: Biological & Chemical Sciences
Group leader: David Cheung

lood-Brain Barrier: Gateway to the mysteries
Viswanath Vittaladevaram, PhD Researcher at the Biological & Chemical Sciences Department at the University of Galway (group leader: David Cheung), send us a picture of the "Blood-Brain Barrier: Gateway to the mysteries": "Due to the complexity of investigating the blood-brain barrier in vivo, it is desirable to create synthetic models of it. Such models will enable the study of disorders of the central nervous system, for example allowing for the study of transport of drugs or other molecules through this and how disruption to this can affect its function. Using molecular simulation, the adsorption of single proteins is investigated, focusing on changes to protein conformation and exposure of binding sites.Model blood-brain barriers can also be used for investigation of drug uptake and screening of candidate drug molecules.

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Charles University Faculty of Medicine in Pilsen

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Education: 2001 MSc in Biochemistry at the Charles University, Faculty of Natural Sciences, Prague, Czech Republic 2006 PhD in Molecular and Cell Biology at the University of South Bohemia, Faculty of Biological Sciences, České Budějovice, Czech Republic Work experience: 2005 – 2007 Institute of Microbiology AS CR, Třeboň, Czech Republic (Research Assistant) 2007 – 2010 University of Glasgow, Faculty of Biomedical and Life Sciences, Glasgow, UK (Research Associate, Prof. Richard Cogdell) 2010 – 2013 University of Glasgow, College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, Glasgow, UK (Research Associate, Prof. Paul Shiels) 2013 – 2018 University of Glasgow, School of Engineering, Division of Biomedical Engineering, Glasgow, UK (Research Associate, Prof. Manuel Salmeron Sanchez) since 2018 Biomedical Center of the Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic (Senior Researcher, Prof. Vaclav Liska)

My expertise lays in the field of tissue engineering and regenerative medicine: Liver, bone and cartilage regeneration with the focus on the development and testing systems using biocompatible natural and synthetic materials that promote regeneration processes; tissue decellularization and characterization; investigation of biomaterial interactions with cells (endothelial, epithelial, stem cells, hepatocytes); studying biomaterials stimulating natural revascularization in situ using very low concentrations of growth factors; material-protein-controlled differentiation of stem cells into different lineages, particularly in osteogenic and chondrogenic lineage combined with promotion of vasculogenesis; in vivo tests of vascularization and bone regeneration; broadly interested in bone, cartilage and liver regeneration.